Jo Ann Janovick Selected Research

LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)

1/2020	Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.
3/2019	Modulation of proteostasis and protein trafficking: a therapeutic avenue for misfolded G protein-coupled receptors causing disease in humans.
4/2011	Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism.
6/2007	Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro.
7/2005	Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants.
5/2005	In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles.
4/2005	A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.
3/2004	Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism.
12/2003	Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism.
12/2003	Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression.

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Jo Ann Janovick Research Topics

Disease

16	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2020 - 05/2002
3	Nephrogenic Diabetes Insipidus 03/2019 - 09/2016
2	Primary Hyperoxaluria (Oxaluria, Primary) 01/2017 - 01/2015
2	Idiopathic Hypogonadotropic Hypogonadism 12/2003 - 07/2003
1	Kidney Diseases (Kidney Disease) 01/2017
1	Primary hyperoxaluria type 1 01/2017
1	Hyperoxaluria (Oxaluria) 01/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 07/2012

Drug/Important Bio-Agent (IBA)

15	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA 01/2020 - 05/2002
6	Proteins (Proteins, Gene)FDA Link 11/2012 - 07/2002
6	Gonadotropin-Releasing Hormone (GnRH)FDA Link 11/2012 - 04/2003
3	Vasopressins (Vasopressin)IBA 03/2019 - 09/2016
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 03/2019 - 07/2012
1	Pharmaceutical PreparationsIBA 01/2017
1	EnzymesIBA 01/2017
1	IonophoresIBA 01/2017
1	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2017
1	Luteinizing Hormone (Lutropin)FDA LinkGeneric 12/2013
1	GonadotropinsIBA 11/2012
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 04/2005
1	Amino Acids FDA Link 12/2003
1	EpitopesIBA 12/2003
1	Cell Surface ReceptorsIBA 04/2003
1	LigandsIBA 07/2002

Therapy/Procedure

1	Kidney Transplantation 01/2017
1	Organ Transplantation 01/2015
1	Therapeutics 01/2015